Urine Metabolites for Estimating Daily Intake of Nicotine From Cigarette Smoking.

ABSTRACT:

Introduction

Accurate measurement of nicotine exposure from cigarette smoke is important in studying disease risk and level of dependence. Urine total nicotine equivalents, the molar sum of nicotine and six metabolites (NE7), accounts for more than 90% of a nicotine dose and is independent of individual metabolic differences. However, measuring NE7 is technically difficult and costly. We compared NE7, the gold standard of nicotine intake, with different combinations of fewer urinary nicotine metabolites. We also examined the impact of individual differences in nicotine metabolic rate, sex, and race on strength of association with NE7.

Methods

Urine samples from 796 daily smokers, who participated across five clinical studies, were assayed for nicotine and/or metabolites. Ass

SUBMITTER: Benowitz NL 

PROVIDER: S-EPMC7297087 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature