Pharmacokinetic Profile of Spectrum Reduced Nicotine Cigarettes.

ABSTRACT:

Introduction

Spectrum research cigarettes have been developed with varying nicotine content for use in studies evaluating the effects of a regulatory policy reducing the permissible nicotine content in cigarettes. This study aimed to characterize the nicotine pharmacokinetic profile of Spectrum cigarettes.

Methods

Twelve daily smokers attended four sessions and had blood nicotine, exhaled carbon monoxide, and subjective effects measured before and after smoking either a single cigarette of their preferred brand or high (10.9 mg/cigarette), medium (3.2 mg/cigarette), or low (0.2 mg/cigarette) nicotine content Spectrum research cigarettes, in a double-blind design with order counterbalanced.

Results

The boost in blood nicotine concentration was dose-dependent, with a bo

SUBMITTER: Kamens HM 

PROVIDER: S-EPMC7297107 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature