Clinical and molecular characteristics of gliosarcoma and modern prognostic significance relative to conventional glioblastoma.

ABSTRACT: Gliosarcoma is a rare histopathologic variant of glioblastoma traditionally associated with a poor prognosis. While gliosarcoma may represent a distinct clinical entity given its unique histologic composition and molecular features, its relative prognostic significance remains uncertain. While treatment of gliosarcoma generally encompasses the same standardized approach used in glioblastoma, supporting evidence is limited given its rarity. Here, we characterized 32 cases of gliosarcoma and retrospectively evaluated survival relative to 451 glioblastoma patients diagnosed during the same era within the same institution. Overall, we identified 22 primary gliosarcomas, representing 4.7% of WHO Grade IV primary glioblastomas, and 10 secondary gliosarcomas. With median age of 62, patients were

SUBMITTER: Smith DR 

PROVIDER: S-EPMC7297205 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature