Protective vascular coagulation in response to bacterial infection of the kidney is regulated by bacterial lipid A and host CD147.

ABSTRACT: Bacterial infection of the kidney leads to a rapid cascade of host protective responses, many of which are still poorly understood. We have previously shown that following kidney infection with uropathogenic Escherichia coli (UPEC), vascular coagulation is quickly initiated in local perivascular capillaries that protects the host from progressing from a local infection to systemic sepsis. The signaling mechanisms behind this response have not however been described. In this study, we use a number of in vitro and in vivo techniques, including intravital microscopy, to identify two previously unrecognized components influencing this protective coagulation response. The acylation state of the Lipid A of UPEC lipopolysaccharide (LPS) is shown to alter the kinetics of local coagulation onset in

SUBMITTER: Schulz A 

PROVIDER: S-EPMC7297223 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature