Comprehensive analysis of gene expression in human retina and supporting tissues.

ABSTRACT: Understanding the influence of gene expression on the molecular mechanisms underpinning human phenotypic diversity is fundamental to being able to predict health outcomes and treat disease. We have carried out whole transcriptome expression analysis on a series of eight normal human postmortem eyes by RNA sequencing. Here we present data showing that ∼80% of the transcriptome is expressed in the posterior layers of the eye and that there is significant differential expression not only between the layers of the posterior part of the eye but also between locations of a tissue layer. These differences in expression also extend to alternative splicing and splicing factors. Differentially expressed genes are enriched for genes associated with psychiatric, immune and cardiovascular disorders. En

SUBMITTER: Li M 

PROVIDER: S-EPMC7297232 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature