Liposome-mediated delivery of challenging chemicals to aid environmental assessment of Bioaccumulative (B) and Toxic (T) properties.

ABSTRACT: Standard aquatic toxicity tests of chemicals are often limited by the chemicals' water solubility. Liposomes have been widely used in the pharmaceutical industry to overcome poor pharmacokinetics and biodistribution. In this work, liposomes were synthesized and used in an ecotoxicological context, as a tool to assure stable dosing of technically challenging chemicals to zooplankton. Three chemicals with distinctly different characteristics were successfully incorporated into the liposomes: Tetrabromobisphenol A (TBBPA, log K_ow 5.9, pK_a1 7.5, pK_a2 8.5), chlorinated paraffin CP-52 (log K_ow 8-12) and perfluorooctanoic acid (PFOA, pK_a 2.8). The size, production yield and stability over time was similar for all blank and chemical-loaded lip

SUBMITTER: Castro M 

PROVIDER: S-EPMC7297709 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature