Adolescent alcohol exposure produces sex differences in negative affect-like behavior and group I mGluR BNST plasticity.

ABSTRACT: Adolescent alcohol exposure increases the risk of developing alcohol use disorders (AUDs), yet the mechanisms responsible for this vulnerability remain largely unknown. One potential target for alcohol-induced changes is the circuitry that modulates negative affect and stress, two sexually dependent drivers of alcohol relapse. The bed nucleus of the stria terminalis (BNST) is a sexually dimorphic region that critically regulates negative affective- and stress-induced relapse. Group I metabotropic glutamate receptors (mGluR) are a target of interest due to their regulation of stress, anxiety behaviors, and BNST plasticity. The current studies investigate sex-dependent sensitivity to the effects of adolescent intermittent ethanol vapor exposure (AIE) on negative affect during acute and protr

SUBMITTER: Kasten CR 

PROVIDER: S-EPMC7297734 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature