HIV-1-Associated Left Ventricular Cardiac Dysfunction in Humanized Mice.

ABSTRACT: The molecular cause(s) for early onset heart failure in people living with HIV-1 infection (PLWH) remains poorly defined. Herein, longitudinal echocardiography was used to assess whether NOD.Cg-Prkdc^scid Il2rgt^m1Wjl/SzJ mice reconstituted with human hematopoietic stem cells (Hu-NSG mice) and infected with HIV-1_ADA can recapitulate the salient features of this progressive human disease. Four weeks post infection, Hu-NSG mice of both sexes developed left ventricular (LV) diastolic dysfunction (DD), with 25% exhibiting grade III/IV restrictive DD with mitral regurgitation. Increases in global longitudinal and circumferential strains and declines in LV ejection fraction and fractional shortening were observed eight weeks post infection. After twelve weeks of in

SUBMITTER: Dash PK 

PROVIDER: S-EPMC7297773 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature