Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain.

ABSTRACT: Women who have experienced adverse childhood events (ACEs) around puberty are at the greatest risk for neuropsychiatric disorders across the lifespan. This population is exceptionally vulnerable to neuropsychiatric disease presentation during the hormonally dynamic state of pregnancy. We previously established that chronic adversity around puberty in female mice significantly altered their HPA axis function specifically during pregnancy, modeling the effects of pubertal ACEs we also reported in women. We hypothesized that the pregnancy hormone, allopregnanolone, was involved in presentation of the blunted stress response phenotype by its interaction with the molecular programming that had occurred during pubertal adversity experience. Here, in adult mice previously stressed during puberty,

SUBMITTER: Morrison KE 

PROVIDER: S-EPMC7297802 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature