In vivo absolute quantification of striatal and extrastriatal D_2/3 receptors with [¹²³I]epidepride SPECT.

ABSTRACT:

Background

[¹²³I]epidepride is a high-affinity radiotracer used in single-photon emission computed tomography (SPECT) imaging of the D_2/3 receptors. It binds with high affinity to striatal and extrastriatal receptors. Nevertheless, its slow kinetics in the striatum impedes quantification in this region. Thus, an approach that would allow a simultaneous quantification of both striatal and extrastriatal D_2/3 receptors would be of interest for preclinical and clinical SPECT neuroimaging. We describe a partial saturation protocol that allows us to produce an in vivo Scatchard plot and thus estimate B_avail and appK_d separately in both striatal and extrastriatal regions, through a single dynamic SPECT session. To validate this approa

SUBMITTER: Tsartsalis S 

PROVIDER: S-EPMC7297889 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature