Maspin as a Prognostic Marker for Early Stage Colorectal Cancer With Microsatellite Instability.

ABSTRACT: Colorectal cancers are among the most common cancers and a leading cause of cancer death. In our pursuit to discover molecular markers for better characterization and precision theranostics of these cancers, we first conducted global deep proteome analyses and identified maspin (serpin B5, peptidase inhibitor 5) as an upregulated protein in tumor tissue. We then validated its expression in a large cohort of 743 patients with colorectal cancers of all stages and found that both cytoplasmic and nuclear expression varied widely between different patients. Comparison with clinicopathological features revealed that maspin expression levels correlate significantly only with mismatch repair (MMR) status but not with other features. To elucidate the prognostic significance of maspin, we analyzed t

SUBMITTER: Tanaka A 

PROVIDER: S-EPMC7297950 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature