K_V11.1 Potassium Channel and the Na⁺/H⁺ Antiporter NHE1 Modulate Adhesion-Dependent Intracellular pH in Colorectal Cancer Cells.

ABSTRACT: Increasing evidence indicates that ion channels and transporters cooperate in regulating different aspects of tumor pathophysiology. In cancer cells, H⁺/HCO₃ ^- transporters usually invert the transmembrane pH gradient typically observed in non-neoplastic cells, which is thought to contribute to cancer malignancy. To what extent the pH-regulating transporters are functionally linked to K⁺ channels, which are central regulators of cell membrane potential (V_m), is unclear. We thus investigated in colorectal cancer cells the implication of the pH-regulating transporters and K_V11.1 (also known as hERG1) in the pH modifications stimulated by integrin-dependent cell adhesion. Colorectal cancer cell lines (HCT 116 and HT 29) were se

SUBMITTER: Iorio J 

PROVIDER: S-EPMC7297984 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature