Motion corrected MRI differentiates male and female human brain growth trajectories from mid-gestation.

ABSTRACT: It is of considerable scientific, medical, and societal interest to understand the developmental origins of differences between male and female brains. Here we report the use of advances in MR imaging and analysis to accurately measure global, lobe and millimetre scale growth trajectory patterns over 18 gestational weeks in normal pregnancies with repeated measures. Statistical modelling of absolute growth trajectories revealed underlying differences in many measures, potentially reflecting overall body size differences. However, models of relative growth accounting for global measures revealed a complex temporal form, with strikingly similar cortical development in males and females at lobe scales. In contrast, local cortical growth patterns and larger scale white matter volume and surfac

SUBMITTER: Studholme C 

PROVIDER: S-EPMC7297991 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature