Psilocybin and LSD have no long-lasting effects in an animal model of alcohol relapse.

ABSTRACT: For most psychiatric disorders, including alcohol use disorder (AUD), approved pharmacological treatments are limited in their effectiveness, and new drugs that can easily be translated into the clinic are needed. Currently, great hope lies in the potential of psychedelics to effectively treat AUD. The primary hypothesis is that a single session of psychedelic-guided psychotherapy can restore normal brain function in AUD individuals and thereby reduce the risk of relapse in the long run. Here we applied three different treatment schedules with psilocybin/LSD in order to investigate relapse-like drinking in the alcohol deprivation effect (ADE) model. In contrast to the primary hypothesis, psychedelics had no long-lasting effects on the ADE in male and female rats, neither when administered

SUBMITTER: Meinhardt MW 

PROVIDER: S-EPMC7298021 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature