Progressive subcortical volume loss in treatment-resistant schizophrenia patients after commencing clozapine treatment.

ABSTRACT: The association of antipsychotic medication with abnormal brain morphometry in schizophrenia remains uncertain. This study investigated subcortical morphometric changes 6 months after switching treatment to clozapine in patients with treatment-resistant schizophrenia compared with healthy volunteers, and the relationships between longitudinal volume changes and clinical variables. In total, 1.5T MRI images were acquired at baseline before commencing clozapine and again after 6 months of treatment for 33 patients with treatment-resistant schizophrenia and 31 controls, and processed using the longitudinal pipeline of Freesurfer v.5.3.0. Two-way repeated MANCOVA was used to assess group differences in subcortical volumes over time and partial correlations to determine association with clinica

SUBMITTER: Tronchin G 

PROVIDER: S-EPMC7298040 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature