Retinal and Optic Nerve Integrity Following Monocular Inactivation for the Treatment of Amblyopia.

ABSTRACT: In animal models, monocular deprivation (MD) by lid closure mimics the effects of unilateral amblyopia in humans. Temporary inactivation of one or both eyes with intraocular administration of tetrodotoxin (TTX) has recently been shown to promote recovery from the anatomical effects of MD at post-critical period ages when standard recovery strategies fail. In the current study, the retinae and optic nerves of animals subjected to 10 days of monocular retinal inactivation were assessed for pathological changes as a means of assessing the viability of this potential new amblyopia therapy. Retinal sections from both eyes were subjected to hematoxylin and eosin staining and were then examined for cell density and soma size in the ganglion cell layer (GCL). Sections of the optic nerve from each

SUBMITTER: DiCostanzo NR 

PROVIDER: S-EPMC7298113 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature