Toxicity Evaluation of TiO₂ Nanoparticles on the 3D Skin Model: A Systematic Review.

ABSTRACT: Titanium dioxide nanoparticles (TiO₂ NPs) are regularly used in sunscreens because of their photoprotective capacity. The advantage of using TiO₂ on the nanometer scale is due to its transparency and better UV blocking efficiency. Due to the greater surface area/volume ratio, NPs become more (bio)-reactive giving rise to concerns about their potential toxicity. To evaluate the irritation and corrosion of cosmetics, 3D skin models have been used as an alternative method to animal experimentation. However, it is not known if this model is appropriate to study skin irritation, corrosion and phototoxicity of nanomaterials such as TiO₂ NPs. This systematic review (SR) proposed the following question: Can the toxicity of TiO₂ nanoparticles be evaluated

SUBMITTER: Sanches PL 

PROVIDER: S-EPMC7298140 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature