Characterization of human respiratory syncytial virus (RSV) isolated from HIV-exposed-uninfected and HIV-unexposed infants in South Africa during 2015-2017.

ABSTRACT:

Background

RSV is a leading cause of lower respiratory tract infection in infants. Monitoring RSV glycoprotein sequences is critical for understanding RSV epidemiology and viral antigenicity in the effort to develop anti-RSV prophylactics and therapeutics.

Objectives

The objective is to characterize the circulating RSV strains collected from infants in South Africa during 2015-2017.

Methods

A subset of 150 RSV-positive samples obtained in South Africa from HIV-unexposed and HIV-exposed-uninfected infants from 2015 to 2017, were selected for high-throughput next-generation sequencing of the RSV F and G glycoprotein genes. The RSV G and F sequences were analyzed by a bioinformatic pipeline and compared to the USA samples from the same three-year period.

Results

B

SUBMITTER: Liu H 

PROVIDER: S-EPMC7298309 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature