Challenge infection model for MERS-CoV based on naturally infected camels.

ABSTRACT:

Background

Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging virus that infects humans and camels with no approved antiviral therapy or vaccine. Some vaccines are in development for camels as a one-health intervention where vaccinating camels is proposed to reduce human viral exposure. This intervention will require an understanding of the prior exposure of camels to the virus and appropriate vaccine efficacy studies in camels.

Methods

We conducted a cross sectional seroprevalence study in young dromedary camels to determine the rate of MERS-CoV seropositivity in young camels. Next, we utilised naturally infected camels as a natural challenge model that can be used by co-housing these camels with healthy naive camels in a ratio of 1 to 2. This model is a

SUBMITTER: Alharbi NK 

PROVIDER: S-EPMC7298446 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature