SARS-CoV-2 infection risk assessment in the endometrium: viral infection-related gene expression across the menstrual cycle.

ABSTRACT:

Objective

To determine the susceptibility of the endometrium to infection by-and thereby potential damage from-SARS-CoV-2.

Design

Analysis of SARS-Cov-2 infection-related gene expression from endometrial transcriptomic data sets.

Setting

Infertility research department affiliated with a public hospital.

Patient(s)

Gene expression data from five studies in 112 patients with normal endometrium collected throughout the menstrual cycle.

Intervention(s)

None.

Main outcome measure(s)

Gene expression and correlation between viral infectivity genes and age throughout the menstrual cycle.

Result(s)

Gene expression was high for TMPRSS4, CTSL, CTSB, FURIN, MX1, and BSG; medium for TMPRSS2; and low for ACE2. ACE2, TMPRSS4, CTSB, CTSL, and MX1 expressio

SUBMITTER: Henarejos-Castillo I 

PROVIDER: S-EPMC7298504 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature