Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy.

ABSTRACT: We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.

SUBMITTER: Paciaroni NG 

PROVIDER: S-EPMC7298663 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature