Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy.
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ABSTRACT:
SUBMITTER: Paciaroni NG
PROVIDER: S-EPMC7298663 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy.
Paciaroni Nicholas G NG Ndungu John M JM Kodadek Thomas T
Chemical communications (Cambridge, England) 20200326 34
We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions. ...[more]
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