Baseline cerebral metabolism predicts fatigue and cognition in Multiple Sclerosis patients.

ABSTRACT:

Background

Cerebral metabolic rate of oxygen (CMRO₂), a measure of global oxygen metabolism, reflects resting cellular activity. The mechanisms underlying fatigue and cognitive dysfunction in multiple sclerosis (MS) remain unknown. If fatigue indeed reflects ongoing autoimmune activity and cortical reorganization, and cognitive decline is the result of gray matter atrophy and white matter degeneration, we postulate that changes in CMRO₂ should reflect disease activity and predict these symptoms.

Objective

We sought to utilize T₂-Relaxation-Under-Spin-Tagging (TRUST) and phase-contrast (PC) MRI to measure global CMRO₂ to understand its relationships to white matter microstructure, fatigue and cognitive dysfunction.

Methods

We

SUBMITTER: West K 

PROVIDER: S-EPMC7298673 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature