Self-Protection against the Sphingolipid Biosynthesis Inhibitor Fumonisin B₁ Is Conferred by a FUM Cluster-Encoded Ceramide Synthase.

ABSTRACT: Fumonisin (FB) mycotoxins produced by species of the genus Fusarium detrimentally affect human and animal health upon consumption, due to the inhibition of ceramide synthase. In the present work, we set out to identify mechanisms of self-protection employed by the FB₁ producer Fusarium verticillioides FB₁ biosynthesis was shown to be compartmentalized, and two cluster-encoded self-protection mechanisms were identified. First, the ATP-binding cassette transporter Fum19 acts as a repressor of the FUM gene cluster. Appropriately, FUM19 deletion and overexpression increased and decreased, respectively, the levels of intracellular and secreted FB₁ Second, the cluster genes FUM17 and FUM18 were shown to be two of five cer

SUBMITTER: Janevska S 

PROVIDER: S-EPMC7298705 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature