Sterol-Response Pathways Mediate Alkaline Survival in Diverse Fungi.

ABSTRACT: The ability for cells to maintain homeostasis in the presence of extracellular stress is essential for their survival. Stress adaptations are especially important for microbial pathogens to respond to rapidly changing conditions, such as those encountered during the transition from the environment to the infected host. Many fungal pathogens have acquired the ability to quickly adapt to changes in extracellular pH to promote their survival in the various microenvironments encountered during a host infection. For example, the fungus-specific Rim/Pal alkaline response pathway has been well characterized in many fungal pathogens, including Cryptococcus neoformans However, alternative mechanisms for sensing and responding to host pH have yet to be extensively studied. Recent observations

SUBMITTER: Brown HE 

PROVIDER: S-EPMC7298709 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature