Establishment of a serological molecular model for the early diagnosis and progression monitoring of bone metastasis in lung cancer.

ABSTRACT:

Background

The prognosis is very poor for lung cancer patients with bone metastasis. Unfortunately, a suitable method has yet to become available for the early diagnosis of bone metastasis in lung cancer patients. The present work describes an attempt to develop a novel model for the early identification of lung cancer patients with bone metastasis risk.

Methods

As the test group, 205 primary lung cancer patients were recruited, of which 127 patients had bone metastasis; the other 78 patients without bone metastasis were set as the negative control. Additionally, 106 healthy volunteers were enrolled as the normal control. Serum levels of several cytokines in the bone microenvironment (CaN, OPG, PTHrP, and IL-6) and bone turnover markers (tP1NP, β-CTx) were detected in all sa

SUBMITTER: Teng X 

PROVIDER: S-EPMC7298761 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature