Two-Phase, Generalized Case-Control Designs for the Study of Quantitative Longitudinal Outcomes.

ABSTRACT: We propose a general class of 2-phase epidemiologic study designs for quantitative, longitudinal data that are useful when phase 1 longitudinal outcome and covariate data are available but data on the exposure (e.g., a biomarker) can only be collected on a subset of subjects during phase 2. To conduct a study using a design in the class, one first summarizes the longitudinal outcomes by fitting a simple linear regression of the response on a time-varying covariate for each subject. Sampling strata are defined by splitting the estimated regression intercept or slope distributions into distinct (low, medium, and high) regions. Stratified sampling is then conducted from strata defined by the intercepts, by the slopes, or from a mixture. In general, samples selected with extreme intercept valu

SUBMITTER: Schildcrout JS 

PROVIDER: S-EPMC7298772 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature