Detection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer.

ABSTRACT:

Background

Crown-like structures in breast adipose tissue (CLS-B), composed of necrotic adipocytes encircled by macrophages, are associated with obesity and hypothesized to worsen breast cancer prognosis; however, data are sparse, particularly in multi-racial populations.

Methods

We assessed specimens for CLS-B from 174 African-American and 168 White women with stage I-III breast cancer treated by mastectomy. Benign breast tissue from an uninvolved quadrant was immunohistochemically stained for CD68 to determine CLS-B presence and density (per cm² of adipose tissue). Demographic and lifestyle factors, collected via medical record review, were analyzed for associations with CLS-B using logistic regression. Multivariable Cox proportional hazards models were used to

SUBMITTER: Maliniak ML 

PROVIDER: S-EPMC7298873 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature