Multilayered mechanisms ensure that short chromosomes recombine in meiosis.

ABSTRACT: In most species, homologous chromosomes must recombine in order to segregate accurately during meiosis¹. Because small chromosomes would be at risk of missegregation if recombination were randomly distributed, the double-strand breaks (DSBs) that initiate recombination are not located arbitrarily². How the nonrandomness of DSB distributions is controlled is not understood, although several pathways are known to regulate the timing, location and number of DSBs. Meiotic DSBs are generated by Spo11 and accessory DSB proteins, including Rec114 and Mer2, which assemble on chromosomes^3-7 and are nearly universal in eukaryotes^8-11. Here we demonstrate how Saccharomyces cerevisiae integrates multiple temporally distinct pathways to regulate the binding o

SUBMITTER: Murakami H 

PROVIDER: S-EPMC7298877 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature