Longitudinal immune cell monitoring identified CD14⁺⁺ CD16⁺ intermediate monocyte as a marker of relapse in patients with ANCA-associated vasculitis.

ABSTRACT:

Background

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease that affects small- to medium-sized blood vessels. Despite treatments having been improved, patients often experience disease relapses. It remains unclear how the immune cells involve in the development of vasculitis and how they fluctuate over the course of treatment. In this study, we aimed to identify the immune subsets and serum cytokines associated with disease relapse by comprehensive immuno-phenotyping in AAV patients.

Methods

We reviewed consecutive patients (n = 29) from Keio University Hospital who had been newly diagnosed with AAV from January 2015 to February 2019 and chronologically followed until 52 weeks. Numbers of circulating T cells, B cells, monocyte

SUBMITTER: Matsumoto K 

PROVIDER: S-EPMC7298936 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature