Apolipoprotein E promotes white matter remodeling via the Dab1-dependent pathway after traumatic brain injury.

ABSTRACT:

Introduction

Axonal injury results in long-term neurological deficits in traumatic brain injury (TBI) patients. Apolipoprotein E (ApoE) has been reported to activate intracellular adaptor protein Disabled-1 (Dab1) phosphorylation via its interaction with ApoE receptors. The Dab1 pathway acts as a regulator of axonal outgrowth and growth cone formation in the brain.

Aims

We hypothesized that ApoE may alleviate axonal injury and regulate axonal regeneration via the Dab1 pathway after TBI.

Results

In this study, we established a model of controlled cortical impact (CCI) to mimic TBI in vivo. Using diffusion tensor imaging to detect white matter integrity, we demonstrated that APOE-deficient mice exhibited lower fractional anisotropy (FA) values than APOE^+/+ mi

SUBMITTER: Huang ZJ 

PROVIDER: S-EPMC7298982 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature