Expression and prognostic role of E2F transcription factors in high-grade glioma.

ABSTRACT:

Introduction

Patients with high-grade glioma (HGG) suffered poor survival due to inherent or acquired therapeutic resistance and refractory recurrence. The outcome of HGG patients has improved little during the past decade. Therefore, molecular signatures are urgently needed for improving diagnosis, survival prediction and identification of therapeutic targets for HGG. E2F transcription factors (E2Fs), a family of transcription factors recognized as master regulators of cell proliferation, have been found to be involved in the pathogenesis of various tumor types.

Aims

To investigate the expression of E2Fs and their prognosis value in high-grade glioma (HGG).

Results

Expression of E2Fs was analyzed in 394 HGG samples from TCGA dataset. E2Fs were generally expressed in

SUBMITTER: Yu H 

PROVIDER: S-EPMC7299000 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature