Prognostic value of HER2 status on circulating tumor cells in advanced-stage breast cancer patients with HER2-negative tumors.

ABSTRACT:

Purpose

Discordance between HER2 expression in tumor tissue (tHER2) and HER2 status on circulating tumor cells (cHER2) has been reported. It remains largely underexplored whether patients with tHER2^-/cHER2⁺ can benefit from anti-HER2 targeted therapies.

Methods

cHER2 status was determined in 105 advanced-stage patients with tHER2^- breast tumors. Association between cHER2 status and progression-free survival (PFS) was analyzed by univariate and multivariate Cox models and survival differences were compared by Kaplan-Meier method.

Results

Compared to the patients with low-risk cHER2 (cHER2⁺  < 2), those with high-risk cHER2 (cHER2⁺  ≥ 2) had shorter survival time and an increased risk for disease progression (hazard

SUBMITTER: Wang C 

PROVIDER: S-EPMC7299127 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature