Assessment of Dynamic Intracranial Compliance in Children with Severe Traumatic Brain Injury: Proof-of-Concept.

ABSTRACT:

Background and aims

Intracranial compliance refers to the relationship between a change in intracranial volume and the resultant change in intracranial pressure (ICP). Measurement of compliance is useful in managing cardiovascular and respiratory failure; however, there are no contemporary means to assess intracranial compliance. Knowledge of intracranial compliance could complement ICP and cerebral perfusion pressure (CPP) monitoring in patients with severe traumatic brain injury (TBI) and may enable a proactive approach to ICP management. In this proof-of-concept study, we aimed to capitalize on the physiologic principles of intracranial compliance and vascular reactivity to CO₂, and standard-of-care neurocritical care monitoring, to develop a method to assess dynamic

SUBMITTER: Wolf MS 

PROVIDER: S-EPMC7299131 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature