Alcohol Consumption and Cardiovascular Disease: A Mendelian Randomization Study.

ABSTRACT:

Background

The causal role of alcohol consumption for cardiovascular disease remains unclear. We used Mendelian randomization (MR) to predict the effect of alcohol consumption on 8 cardiovascular diseases.

Methods

Up to 94 single-nucleotide polymorphisms were used as instrumental variables for alcohol consumption. Genetic association estimates for cardiovascular diseases were obtained from large-scale consortia and UK Biobank. Analyses were conducted using the inverse variance-weighted, weighted median, MR-PRESSO, MR-Egger, and multivariable MR methods.

Results

Genetically predicted alcohol consumption was consistently associated with stroke and peripheral artery disease across the different analyses. The odds ratios (ORs) per 1-SD increase of log-transformed alcoholi

SUBMITTER: Larsson SC 

PROVIDER: S-EPMC7299220 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature