Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level.

ABSTRACT: Goal-directed behavior requires the interaction of multiple brain regions. How these regions and their interactions with brain-wide activity drive action selection is less understood. We have investigated this question by combining whole-brain volumetric calcium imaging using light-field microscopy and an operant-conditioning task in larval zebrafish. We find global, recurring dynamics of brain states to exhibit pre-motor bifurcations toward mutually exclusive decision outcomes. These dynamics arise from a distributed network displaying trial-by-trial functional connectivity changes, especially between cerebellum and habenula, which correlate with decision outcome. Within this network the cerebellum shows particularly strong and predictive pre-motor activity (>10 s before movement initiati

SUBMITTER: Lin Q 

PROVIDER: S-EPMC7299501 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature