The prognostic significance of GRB7 protein expression and localization in human breast and ovarian cancers.

ABSTRACT: Objective: To study GRB7 protein expression in normal human tissues and breast and ovarian cancers, and determine its clinical significance. Results: GRB7 protein was expressed in multiple tissues, including myoepithelial cells of normal breast and fibroadenoma. Cytoplasmic GRB7 expression was seen predominantly in HER-2 positive and, to a lesser extent, triple negative breast cancer. Membrane localization of GRB7 was present in a subset of breast cancers with high cytoplasmic GRB7 expression. Univariate and multivariate analysis found that cytoplasmic GRB7 expression was associated with a negative progesterone receptor status, while membrane GRB7 expression was associated with a negative axillary nodal status. Membrane associated GRB7 expression was present in a subset of ov

SUBMITTER: Vermehren-Schmaedick A 

PROVIDER: S-EPMC7299530 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature