Pedunculopontine Nucleus Cholinergic Deficiency in Cervical Dystonia.

ABSTRACT:

Background

The etiology of cervical dystonia is unknown. Cholinergic abnormalities have been identified in dystonia animal models and human imaging studies. Some animal models have cholinergic neuronal loss in the striatum and increased acetylcholinesterase activity in the pedunculopontine nucleus.

Objectives

The objective of this study was to determine the presence of cholinergic abnormalities in the putamen and pedunculopontine nucleus in cervical dystonia human brain donors.

Methods

Formalin-fixed brain tissues were obtained from 8 cervical dystonia and 7 age-matched control brains (controls). Pedunculopontine nucleus was available in only 6 cervical dystonia and 5 controls. Neurodegeneration was evaluated pathologically in the putamen, pedunculopontine nucleus, an

SUBMITTER: Mente K 

PROVIDER: S-EPMC7299544 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature