Genetically Determined Birthweight Associates With Atrial Fibrillation: A Mendelian Randomization Study.

ABSTRACT:

Background

Atrial fibrillation is a common cardiovascular disorder, characterized by irregular electrical activity in the upper chambers of the heart. Both chronic cardiometabolic risk factors and genetics have been shown to contribute to the development of atrial fibrillation. Birthweight has also been associated with risk of atrial fibrillation.

Methods

In the current study, we utilized a genetic approach to study the effect of birthweight on atrial fibrillation. We used 2-sample Mendelian randomization to consider the impact of birthweight on incident atrial fibrillation using summary data from the Early Growth Genetics Consortium GWAS of birthweight and a large biobank-based GWAS of atrial fibrillation.

Results

Using the framework of 2-sample Mendelian randomizati

SUBMITTER: Kember RL 

PROVIDER: S-EPMC7299774 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature