P50 inhibitory sensory gating in schizophrenia: analysis of recent studies.

ABSTRACT:

Introduction

Inhibitory sensory gating of the P50 cerebral evoked potential to paired auditory stimuli (S1, S2) is a widely used paradigm for the study of schizophrenia and related conditions. Its use to measure genetic, treatment, and developmental effects requires a metric with more stable properties than the simple ratio of the paired responses.

Methods

This study assessed the ratio P50_S2μV/P50_S1μV and P50_S2μV co-varied for P50_S1μV in all 27 independent published studies that compared schizophrenia patients with healthy controls from 2000 to 2019. The largest study from each research group was selected. The Colorado research group's studies were excluded to eliminate bias from the first report of the phenomenon.

Results

A

SUBMITTER: Freedman R 

PROVIDER: S-EPMC7299819 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature