Combined effects of HIV and obesity on the gastrointestinal microbiome of young men who have sex with men.

ABSTRACT:

Objectives

The prevalence of obesity is rising among people living with HIV, which may synergistically increase inflammation and the risk of associated diseases. Disruption of gut bacterial communities may be one of the key drivers of this inflammation; however, the combined effects of HIV and obesity on the microbiome have not been explored.

Methods

This study included 381 men who have sex with men. Thirty-nine were HIV-positive and obese (H+O+), 143 were HIV-positive and nonobese, 64 were HIV-negative and obese, and 135 were HIV-negative and nonobese. Microbiome composition was assessed by targeted sequencing of the V4 region of the 16S ribosomal RNA (rRNA) gene using rectal swab samples. Inverse probability of treatment-weighted marginal structural models were used to inv

SUBMITTER: Cook RR 

PROVIDER: S-EPMC7299823 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature