Neural Selective Cryoneurolysis with Ice Slurry Injection in a Rat Model.

ABSTRACT:

Background

Postoperative pain caused by trauma to nerves and tissue around the surgical site is a major problem. Perioperative steps to reduce postoperative pain include local anesthetics and opioids, the latter of which are addictive and have contributed to the opioid epidemic. Cryoneurolysis is a nonopioid and long-lasting treatment for reducing postoperative pain. However, current methods of cryoneurolysis are invasive, technically demanding, and are not tissue-selective. This project aims to determine whether ice slurry can be used as a novel, injectable, drug-free, and tissue-selective method of cryoneurolysis and resulting analgesia.

Methods

The authors developed an injectable and selective method of cryoneurolysis using biocompatible ice slurry, using rat sciatic nerv

SUBMITTER: Garibyan L 

PROVIDER: S-EPMC7299828 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature