In vivo characterization of [¹⁸F]AVT-011 as a radiotracer for PET imaging of multidrug resistance.

ABSTRACT:

Purpose

Multidrug resistance (MDR) impedes cancer treatment. Two efflux transporters from the ATP-binding cassette (ABC) family, ABCB1 and ABCG2, may contribute to MDR by restricting the entry of therapeutic drugs into tumor cells. Although a higher expression of these transporters has been correlated with an unfavorable response to chemotherapy, transporter expression does not necessarily correlate with function. In this study, we characterized the pharmacological properties of [¹⁸F]AVT-011, a new PET radiotracer for imaging transporter-mediated MDR in tumors.

Methods

AVT-011 was radiolabeled with ¹⁸F and evaluated with PET imaging in preclinical models. Transport of [¹⁸F]AVT-011 by ABCB1 and/or ABCG2 was assessed by measuring its uptake in

SUBMITTER: Kannan P 

PROVIDER: S-EPMC7299908 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature