Highly reliable, targeted photothermal cancer therapy combined with thermal dosimetry using a near-infrared absorbent.

ABSTRACT: Photothermal therapy (PTT) using a photo-absorbent in the near-infrared (NIR) region is an effective methodology for local cancer treatment. Before PTT using a NIR absorbent is executed, the operator generally determines the two parameters of fluence rate and irradiation time. However, even if the irradiation parameters are unchanged, the therapeutic effect of PTT is often different for individual tumors. Hence, we examined the therapeutic effect of PTT using a NIR absorbent (ICG lactosome) while changing two parameters (fluence rate and irradiation time) in various combinations. As a result, there was no robust correlation between those parameters and the therapeutic effect. Compared to those parameters, we found that a more reliable determinant was maintenance of the tumor temperature ab

SUBMITTER: Nomura S 

PROVIDER: S-EPMC7299938 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature