Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system.

ABSTRACT: Accumulating evidence demonstrates that not only sustained elevation of blood glucose levels but also the glucose fluctuation represents key determinants for diabetic complications and mortality. Current closed-loop insulin therapy option is limited to the use of electronics-based systems, although it poses some technical issues with high cost. Here we demonstrate an electronics-free, synthetic boronate gel-based insulin-diffusion-control device technology that can cope with glucose fluctuations and potentially address the electronics-derived issues. The gel was combined with hemodialysis hollow fibers and scaled suitable for rats, serving as a subcutaneously implantable, insulin-diffusion-active site in a manner dependent on the subcutaneous glucose. Continuous glucose monitoring tests re

SUBMITTER: Matsumoto A 

PROVIDER: S-EPMC7299969 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature