Associations among neurophysiology measures in irritable bowel syndrome (IBS) and their relevance for IBS symptoms.

ABSTRACT: Abnormal gut-brain interactions are common in irritable bowel syndrome (IBS), but the associations between neurophysiological measures and their relation to gastrointestinal (GI) symptoms are poorly understood. Our aim was to explore these relationships and define the most relevant neurophysiology measures for GI symptom severity in IBS. IBS patients underwent small intestinal motility (manometry; fasted and fed contraction frequency, phase III time) and secretion (transmural potential difference), rectal sensorimotor (barostat; sensory thresholds, tone response, compliance), autonomic nervous system (baroreceptor sensitivity and effectiveness), and colonic motor function (transit time) examinations. GI symptom severity (GSRS-IBS), and anxiety and depression (HAD) as a proxy measure of cen

SUBMITTER: Midenfjord I 

PROVIDER: S-EPMC7300023 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature