Photochemistry of nitric oxide and S-nitrosothiols in human skin.

ABSTRACT: Nitric oxide (NO) is related to a wide range of physiological processes such as vasodilation, macrophages cytotoxicity and wound healing. The human skin contains NO precursors (NO_x). Those are mainly composed of nitrite (NO₂^-), nitrate (NO₃^-), and S-nitrosothiols (RSNOs) which forms a large NO store. These NO_x stores in human skin can mobilize NO to blood stream upon ultraviolet (UV) light exposure. The main purpose of this study was to evaluate the most effective UV light wavelength to generate NO and compare it to each NO precursor in aqueous solution. In addition, the UV light might change the RSNO content on human skin. First, we irradiated pure aqueous solutions of NO₂^- and NO₃^-

SUBMITTER: Pelegrino MT 

PROVIDER: S-EPMC7300104 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature