Binding of [¹⁸F]AV1451 in post mortem brain slices of semantic variant primary progressive aphasia patients.

ABSTRACT:

Purpose

In vivo tau-PET tracer retention in the anterior temporal lobe of patients with semantic variant primary progressive aphasia (SV PPA) has consistently been reported. This is unexpected as the majority of these patients have frontotemporal lobar degeneration TDP (FTLD-TDP).

Methods

We conducted an in vitro [¹⁸F]AV1451 autoradiography binding study in five cases with a clinical diagnosis of SV PPA constituting the range of pathologies (i.e., three FTLD-TDP, one Alzheimer's disease (AD), and one Pick's disease (PiD)). Binding was compared with two controls without neurodegeneration, two typical AD, one corticobasal syndrome with underlying AD, and one frontotemporal dementia behavioral variant with FTLD-TDP. The effect of blocking with the authentic reference

SUBMITTER: Schaeverbeke J 

PROVIDER: S-EPMC7300115 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature