Software simulation of tumour motion dose effects during flattened and unflattened ITV-based VMAT lung SBRT.

ABSTRACT:

Purpose

Restricted studies comparing different dose rate parameters are available while ITV-based VMAT lung SBRT planning leads to perform the analysis of the most suitable parameters of the external beams used. The special emphasis was placed on the impact of dose rate on dose distribution variations in target volumes due to interplay effects.

Methods

Four VMAT plans were calculated for 15 lung tumours using 6 MV photon beam quality (flattening filter FF vs. flattening filter free FFF beams) and maximum dose rate of 600 MU/min, 1000 MU/min and 1400 MU/min. Three kinds of motion simulations were performed finally giving 180 plans with perturbed dose distributions.

Results

6FFF-1400 MUs/min plans were characterized by the shortest beam on time (1.8 ± 0.2 min). Analysin

SUBMITTER: Adamczyk M 

PROVIDER: S-EPMC7300152 | biostudies-literature | 2020 Jul-Aug

REPOSITORIES: biostudies-literature