Influence of sampling schedules on [¹⁷⁷Lu]Lu-PSMA dosimetry.

ABSTRACT:

Background

Individualized dosimetry is recommended for [¹⁷⁷Lu]Lu-PSMA radioligand therapy (RLT) which is resource-intensive and protocols are often not optimized. Therefore, a simulation study was performed focusing on the determination of efficient optimal sampling schedules (OSS) for renal and tumour dosimetry by investigating different numbers of time points (TPs).

Methods

Sampling schedules with 1-4 TPs were investigated. Time-activity curves of the kidneys and two tumour lesions were generated based on a physiologically based pharmacokinetic (PBPK) model and biokinetic data of 13 patients who have undergone [¹⁷⁷Lu]Lu-PSMA I&T therapy. Systematic and stochastic noise of different ratios was considered when modelling time-activity data sets. Time-int

SUBMITTER: Rinscheid A 

PROVIDER: S-EPMC7300169 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature