Chromatin-remodeling links metabolic signaling to gene expression.

ABSTRACT:

Background

ATP-dependent chromatin remodelers are evolutionarily conserved complexes that alter nucleosome positioning to influence many DNA-templated processes, such as replication, repair, and transcription. In particular, chromatin remodeling can dynamically regulate gene expression by altering accessibility of chromatin to transcription factors.

Scope of review

This review provides an overview of the importance of chromatin remodelers in the regulation of metabolic gene expression. Particular emphasis is placed on the INO80 and SWI/SNF (BAF/PBAF) chromatin remodelers in both yeast and mammals. This review details discoveries from the initial identification of chromatin remodelers in Saccharomyces cerevisiae to recent discoveries in the metabolic requirements of developin

SUBMITTER: Morrison AJ 

PROVIDER: S-EPMC7300377 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature